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R&D

Extraction from herbaceous matrices

  • Supercritical fluid extraction (SFE) of essential oils, resin oils, dyes, active principles from vegetable matrices (roots, leaves, rhizomas, flowers); fields of interest: food, cosmetic, pharmaceutical industry
  • Extraction of biologically active molecules from solid natural stuff, as medicinal plants; particular interest is addressed to chlorinated and organic solvents substitution
  • Extraction and fractionation of active molecules from diluted media, as fermentation broth, or from natural and synthetic liquid sources
  • Production of enriched fractions
  • Dewaxing of natural products


Fractionation of liquid feeds

  • Husk oil, refined oil, and rape oil treatment for acidity and sterolic content reduction, pigments (charotenoids, chlorofill) and waxes removal
  • Recovery of tocopherols from deodorizer condensates oils

Purification of synthetic-end products

  • Organic solvent removal from pharmaceuticals (dichloromethane, isobuthyl alcohol)
  • Substitution of chlorinated solvents in cosmetics industry

Impregnation

  • Inpregnation of synthetic or natural polymer matrices for preparing highly disperded catalysts, controlled drug delivery systems or to improve the matrix properties┬átablet coating, to avoid the use of organic solvents

Powder technology

  • Crystallization and atomization through the rapid expansion of a supercritical solution (RESS, rapid expansion of supercritical solution): application to antibiothic (salicylic acid), antimicotics (griseofulvin), hormones (progesteron, testosteron)
  • Precipitation induced by SC antisolvent effect (SAS, supercritical antisolvent precipitation) starting from homogeneous solutions: batch and continuous process; application to biopolymers and drugs (ialuronic acid, pentamidine, salbuthanol)
  • Encapsulation of pharmaceuticals with biocompatible polymers (ethylcellulose, acrylic polymers) via SAS technique starting from heterogeneous solutions: batch process

Reactions

  • Reaction and fractionation combination with possibility of organic solvent substitution, easy downward processing permitting reactants recycle and high reaction rates in relation with high diffusivity in the supercritical (SC) solvent
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